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Qihuang Granule
- Development stage
- Preclinical
- Lead developer
- Eye Hospital of China Academy of Chinese Medical Sciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Qihuang Granule (QHG) is a Traditional Chinese Medicine (TCM) herbal formula specifically developed for the treatment of dry age-related macular degeneration (dry AMD). It exerts its therapeutic effects by protecting the retinal pigment epithelium (RPE) and the inner segment/outer segment (IS/OS) layers of the retina from oxidative stress-induced damage. Mechanistically, QHG appears to regulate the alternative complement pathway by promoting the expression of complement factor H (CFH) and inhibiting the production of pro-inflammatory complement components C3a and C5a. Additionally, it has been shown to alleviate mitochondrial damage in RPE cells, thereby preventing cell apoptosis and maintaining retinal structural integrity.
- Other names
- Qihuang Granule
02
Targets
CFH (Complement factor H)C3AR1 (Complement C3a receptor)Complement component C5a
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