Drug intelligence / Profile preview

qihuang jiangtang jiaonang

Development stage
Unknown
Lead developer
Shandong Yidaokang Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Qihuang Jiangtang Jiaonang (also known as Qihuang Jiangtang Capsule or QHJTC) is a multi-component Traditional Chinese Medicine (TCM) formulation approved by the China Food and Drug Administration (CFDA) in 2017 for the treatment of type 2 diabetes mellitus (T2DM). Marketed under the brand name Yidaokang, it is specifically indicated for patients presenting with Qi and Yin deficiency and heat syndrome. The formulation is composed of various herbal ingredients, including Astragalus membranaceus and Polygonatum sibiricum, which work synergistically to regulate glucose metabolism, enhance insulin signaling, and reduce levels of inflammatory cytokines and reactive oxygen species. Network pharmacology studies have identified potential targets such as AKT1, TNF, and IL-6, suggesting a multi-pathway mechanism of action to improve insulin resistance and protect pancreatic function. It is typically administered orally as an adjunct to standard therapies like metformin.

Brand names
Yidaokang益道康
Other names
Qihuang Jiangtang CapsuleQHJTC杞黄降糖胶囊
02

Targets

VEGFA (Vascular endothelial growth factor A)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)INSR (Insulin receptor)TP53 (Cellular Tumor Antigen p53 R175H)IL-6 (Interleukin 6)CASP3 (Caspase-3)

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