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Qihuang Yishen Granule

Development stage: Unknown
Lead developer: China Academy of Chinese Medical Sciences
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Qihuang Yishen Granule (also known as TCM2501) is a traditional Chinese medicine (TCM) herbal formula developed as a hospital preparation by Wangjing Hospital of the China Academy of Chinese Medical Sciences, and licensed to Tasly for further clinical development. It is formulated from five traditional herbs: Huangqi (*Astragalus membranaceus*), Dihuang (*Rehmannia glutinosa*), Shanzhuyu (*Cornus officinalis*), Danshen (*Salvia miltiorrhiza*), and Danggui (*Angelica sinensis*). Qihuang Yishen Granule is primarily developed for the treatment of diabetic kidney disease (DKD) and diabetic nephropathy, where it aims to reduce proteinuria and alleviate renal fibrosis. Mechanistically, the formula has been shown to attenuate renal tubular injury and podocyte epithelial-mesenchymal transition (EMT) by downregulating the expression of lncRNA MALAT1, inhibiting the Wnt/β-catenin signaling pathway, and modulating inflammation via the cGAS/STING pathway.

Other names: QHYSQHYS GranulesQihuang Yishen FormulaQihuang Yishen Granules芪黄益肾方芪黄益肾颗粒

Targets

MALAT1 (Metastasis associated lung adenocarcinoma transcript 1)SMAD3 (SMAD family member 3)

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