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Qijian mixture
- Development stage
- Preclinical
- Lead developer
- Beijing University of Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Qijian mixture is a traditional Chinese medicine (TCM) formula comprising *Astragalus membranaceus*, *Ramulus euonymi*, *Coptis chinensis*, and *Pueraria lobata*, developed for the treatment of type 2 diabetes (T2D). The formula exerts its therapeutic effects through a multi-target approach, including the modulation of gut microbiota (specifically enriching the Bacteroidetes phylum) and the regulation of metabolic pathways such as galactose metabolism and amino acid degradation. System pharmacology analysis indicates that Qijian mixture acts via key signaling proteins, including AKT1, PPARA, and TP53. Preclinical studies in diabetic mouse models have demonstrated its efficacy in lowering blood glucose levels and its safety profile, showing a similar hypoglycemic trend to metformin.
- Other names
- Qijian Mixture
02
Targets
PPARA (Peroxisome proliferator-activated receptor alpha)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)
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