Drug intelligence / Profile preview

Qiling Tiaoyuan Decoction

Development stage
Unknown
Lead developer
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
Administration
Oral
01

Overview

Qiling Tiaoyuan Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, affiliated with the Shanghai University of TCM. It is specifically formulated for the treatment of advanced gastric cancer, particularly in patients classified under the TCM syndrome of deficiency of the middle jiao and qi stagnation. The decoction is typically used as an adjuvant therapy in combination with standard chemotherapy regimens, such as XELOX (oxaliplatin and capecitabine). Its therapeutic objectives include tonifying the spleen, replenishing qi, and regulating the middle jiao to improve patient quality of life, mitigate chemotherapy-induced side effects, and potentially enhance the overall anti-tumor response in stage IV gastric cancer patients.

Other names
芪苓调元汤
02

Targets

Interleukin-6/Signal transducer and activator of transcription 3 signaling axisTP53 (Cellular Tumor Antigen p53 R175H)VEGFA (Vascular endothelial growth factor A)Hypoxia-inducible factor 1-alpha/Vascular endothelial growth factor A signaling axisESR1 (ERα)S100A4 (Ferroptosis suppressor protein 1)CASP3 (Caspase-3)

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