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Qing-Huang San
- Development stage
- Unknown
- Lead developer
- China Academy of Chinese Medical Sciences
- Administration
- Oral
01
Overview
Qing-Huang San (QHS) is a traditional Chinese medicine (TCM) herbal formula primarily composed of Realgar (containing tetraarsenic tetrasulfide, $As_4S_4$) and Indigo Naturalis (containing indigo and indirubin). Developed and extensively studied by Xiyuan Hospital of the China Academy of Chinese Medical Sciences, Qing-Huang San is used for the treatment of hematological malignancies, particularly myelodysplastic syndrome (MDS) and acute promyelocytic leukemia (APL). The formula works synergistically: tetraarsenic tetrasulfide acts as the principal active component to induce cell differentiation and apoptosis, while indirubin from Indigo Naturalis acts as an adjuvant to enhance arsenic uptake (via up-regulation of aquaglyceroporin 9, AQP9) and inhibit cyclin-dependent kinases (CDKs). In MDS, Qing-Huang San has been shown to regulate DNA methylation (acting as a dual methyltransferase modulator with both demethylating and pro-methylating effects) and target the TP53/pVHL/HIF1A signaling pathways.
- Other names
- Qing-Huang-SanQing-Huang capsuleQing-Huang capsulesQinghuang SanQinghuang capsuleQinghuang capsulesQinghuang powder青黄散青黄胶囊
02
Targets
BCL-2 (BCL-2 family)CDK1 (Cyclin-dependent kinase 1)CDK2 (Cyclin-dependent kinase 2)DNMT1 (DNA (cytosine-5)-methyltransferase 1)DNMT3A (DNA methyltransferase 3 alpha)DNMT3B (DNA (cytosine-5)-methyltransferase 3B)PML-RARA (PML-retinoic acid receptor alpha fusion protein)PML (Promyelocytic leukemia protein)
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