Drug intelligence / Profile preview

qing re huo xue

Development stage
Phase 3
Lead developer
Guang'anmen Hospital
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral, Topical
01

Overview

Qing Re Huo Xue (QRHX) is a traditional Chinese medicine (TCM) formulation used primarily for the treatment of inflammatory and vascular conditions. It is most commonly administered as a decoction (Qingre Huoxue decoction; QRHXD), but also exists in external preparation forms (QRHXEP). The formula typically contains multiple herbal ingredients such as Ligusticum wallichii, Radix Paeoniae Rubra, Lignum acronychiae, Safflower (Carthamus tinctorius), Salvia miltiorrhiza (Danshen), Scutellaria baicalensis, and Ilex pubescens[7]. Its mechanism of action involves "clearing heat" and "promoting blood circulation," which translates to anti-inflammatory effects and improvement of microcirculation in biomedical terms. Modern studies suggest that it modulates angiogenic and inflammatory pathways[9], impacts metabolic pathways relevant to inflammation[2], delays radiological progression in rheumatoid arthritis[6], alleviates symptoms with fewer side effects than conventional DMARDs[1][3], promotes wound healing[4][9], and may have multi-targeted effects on cancer cells such as pancreatic cancer[5]. It is used both alone or adjunctively with standard therapies like methotrexate for rheumatoid arthritis.

Brand names
Qingre Huayu Formula
Other names
Qingre Huoxue decoctionQingre Huoxue prescriptionQingreHuoxue treatment
02

Targets

IL-6 (Interleukin 6)IL10 (Interleukin-10)VEGFA (Vascular endothelial growth factor A)HIF1A (Hypoxia-inducible factor 1-alpha)TNFA (Tumor necrosis factor alpha (soluble))VEGFR-1 (Vascular endothelial growth factor receptor 1)

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