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Qingchang Xiaopi Decoction
- Development stage
- Preclinical
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
Qingchang Xiaopi Decoction is a traditional Chinese herbal prescription used primarily for the treatment of ulcerative colitis (UC) in China. It is formulated as a multi-herb decoction and has demonstrated efficacy in alleviating symptoms such as diarrhea, abdominal pain, abdominal distension, and purulent stool in patients with mild-to-moderate UC. The mechanism of action appears to involve reduction of inflammatory cytokines (notably IL-6, IL-17, and IL-23), moderation of pathogenic T-helper 17 (Th17) cell activity, and inhibition of STAT3 phosphorylation. These effects collectively contribute to the alleviation of intestinal inflammation associated with UC[1]. The main components have been identified by UHPLC-Q-TOF-MS analysis; however, specific constituent herbs are not detailed in the available summary.
- Brand names
- Qingchang Xiaopi Decoction
- Other names
- QCXPYQingChang-XiaoPi decoction
02
Targets
IL-23 (Interleukin-23)IL-6 (Interleukin 6)IL-17A (Interleukin-17A)STAT3 (Signal Transducer and Activator of Transcription 3)
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