Qingchang Yuyang Decoction

Qingchang Yuyang Decoction is a **traditional Chinese medicine (TCM) herbal formula** utilized for the management of ulcerative colitis (UC). It is composed of a mixture of multiple Chinese medicinal herbs, often including *Huangqin* (Scutellaria baicalensis), *Baitouweng* (Pulsatilla chinensis), *Tufuling* (Smilax glabra), *Baishao* (Paeonia lactiflora), *Diyu* (Sanguisorba officinalis), *Qiancao* (Rubia cordifolia), *Xuchangqing* (Cynanchum paniculatum), *Baizhi* (Angelica dahurica), and *Gancao* (Glycyrrhiza uralensis) blended in specific proportions. The decoction is traditionally prepared by boiling these herbs in water and concentrating the extract[2]. The main therapeutic benefit is **amelioration of ulcerative colitis** symptoms: reducing inflammation, enhancing mucosal barrier function, adjusting intestinal flora, and improving colonic energy metabolism. Modern studies suggest its action involves activation of the **peroxisome proliferator-activated receptor gamma (PPAR-γ)**, influencing mitochondrial TCA cycle activity, leading to decreased expansion of pathogenic facultative anaerobes such as certain pathogenic *Escherichia coli*. Notable representative constituents include baicalin, paeoniflorin, mollugin, and imperatorin, shown to interact with PPAR-γ[1][2]. Clinical studies indicate that, when used in combination with standard therapies such as mesalazine, the decoction further improves clinical outcomes, inflammatory markers, and composition of gut flora, reducing harmful *Enterococcus* and *Enterobacter* while increasing beneficial bacteria like *Bifidobacterium*, *Butyric Clostridium*, and *Lactobacillus*[3][5][8][9].

Brand names

Qingchang Yuyang Decoction

Other names

QCYD