Qingdao Univ. HDAC6 compound 20c

Qingdao Univ. HDAC6 compound 20c: sourced facts only. name: "Herein, we report a group of novel hydrophobic tag based HDAC6 degraders by modifying the structure of Nexturastat A and identified 20c as a lead compound which selectively degrades HDAC6 in vitro (half-degradation concentration = 1.1 μM) in a ubiquitin-proteasome system dependent manner without obviously impacting six other HDAC isoforms." [PMID:42593926]; target: "Herein, we report a group of novel hydrophobic tag based HDAC6 degraders by modifying the structure of Nexturastat A and identified 20c as a lead compound which selectively degrades HDAC6 in vitro (half-degradation concentration = 1.1 μM) in a ubiquitin-proteasome system dependent manner without obviously impacting six other HDAC isoforms." [PMID:42593926]; developer: "Department of Pharmacology, School of Pharmacy, Qingdao Medical College of Qingdao University, Qingdao University, Qingdao266073, China." [PMID:42593926]; stage: "In a dextran sulfate sodium (DSS)-induced colitis model, 20c alleviated disease symptoms, reduced colon shortening, and downregulated pro-inflammatory cytokines." [PMID:42593926]