Drug intelligence / Profile preview

qingfehuatan decoction

Development stage
Unknown
Lead developer
China-Japan Friendship Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

Qingfehuatan decoction is a Traditional Chinese Medicine (TCM) formula developed by the China-Japan Friendship Hospital, specifically indicated for the treatment of bronchiectasis, particularly during acute exacerbations characterized by phlegm-heat obstructing the lungs. The decoction is a complex herbal mixture typically containing ingredients such as *Scutellaria baicalensis* (Huangqin), *Fritillaria thunbergii* (Zhebeimu), and *Morus alba* (Sangbaipi). Its therapeutic effects are attributed to its multi-target anti-inflammatory and mucoregulatory properties. Mechanistically, it has been shown to reduce the levels of pro-inflammatory cytokines, including interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), in the airways. Additionally, it acts as a mucoregulator by potentially downregulating the expression of MUC5AC, thereby reducing airway mucus hypersecretion and improving mucociliary clearance. Clinical research at the China-Japan Friendship Hospital has focused on its ability to alleviate cough, reduce sputum volume, and decrease the frequency of exacerbations in patients with chronic inflammatory airway diseases.

Other names
Qingfei Huatan decoctionQingfei Huatan Tang
02

Targets

IL8 (C-X-C Motif Chemokine Ligand 8)TNFA (Tumor necrosis factor alpha (soluble))MUC5AC (Mucin-5AC)

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