Drug intelligence / Profile preview

Qingfei Dayuan Granule

Development stage
Phase 2
Lead developer
Jinpai Chizhengtang Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Qingfei Dayuan Granule is a traditional Chinese medicine (TCM) herbal formulation developed as granules for oral administration. It is primarily used for the treatment of influenza and upper respiratory tract infections (URTIs), especially those characterized by pulmonary heat-toxin syndrome in TCM. The formulation contains multiple herbal ingredients and exerts its effects through multi-ingredient, multi-target actions including anti-inflammatory and immune-modulating activities[3][4]. Preclinical studies demonstrate significant anti-inflammatory and antitussive effects, with a favorable safety profile at clinically relevant doses[5]. Clinical trials have shown that it can shorten fever duration and alleviate symptoms such as sore throat, nasal congestion, sneezing, headache, and cough in patients with influenza or URTIs[6][7]. Mechanistically, network pharmacology analyses suggest that the granules act on inflammatory pathways and immune system modulation to exert their therapeutic effect[3][4].

Brand names
Qingfei Dayuan Granule
Other names
QFDYQing-Fei-Da-Yuan Granule清肺达原颗粒
02

Targets

AR (Adrenergic receptors)ACE2 (Angiotensin-converting enzyme 2)EGFR (Epidermal growth factor receptor)ESR1 (ERα)MMP2 (Matrix metalloproteinase-2)Mpro (3C-like proteinase of SARS-CoV-2)VEGFR2 (Vascular endothelial growth factor receptor 2)

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