Drug intelligence / Profile preview

Qingfei Pingchuan

Development stage
Phase 2
Lead developer
Liaoning University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Qingfei Pingchuan is a Traditional Chinese Medicine (TCM) formulation primarily used for the treatment of respiratory disorders such as bronchial asthma and chronic bronchitis. Its name is a literal translation of its therapeutic actions: clearing lung-heat and relieving asthma (wheezing). The medication is typically a multi-herbal combination, with standard formulations containing *Ephedra sinica* (Mahuang), *Scutellaria baicalensis* (Huangqin), *Gypsum fibrosum* (Shigao), and *Armeniaca sibirica* (Xingren). Its mechanism of action involves bronchodilation through the activation of β2-adrenergic receptors by ephedrine alkaloids, as well as anti-inflammatory activity mediated by the inhibition of pro-inflammatory cytokines such as TNF-α and IL-6. It is commercially available in China in capsule and granule forms and is frequently indicated for patients presenting with symptoms of lung-heat syndrome, including cough, yellow phlegm, and shortness of breath.

Brand names
Qingfei Pingchuan CapsuleQingfei Pingchuan Granule
Other names
Clearing lung and relieving asthmaticQingfei Pingchuan KeliCLRA
02

Targets

ADRA1A (α1A)ADRB2 (β2)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))

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