Drug intelligence / Profile preview

qinghao + biejia

Development stage: Preclinical
Lead developer: Zhejiang Chinese Medical University
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Qinghao + Biejia is a traditional Chinese medicine (TCM) herb pair consisting of Qinghao (Artemisia annua L.) and Biejia (Carapax Trionycis). It serves as the core component of the Jieduquyuziyin prescription, primarily utilized for its immunomodulatory and anti-inflammatory properties. The combination is extensively studied for the treatment of systemic lupus erythematosus (SLE) and its associated complications, such as lupus nephritis and atherosclerosis (SLE-AS). Its therapeutic mechanism involves the regulation of the HMGB1/TLR4 signaling pathway, inhibition of inflammatory cytokines such as Interleukin-6 (IL-6) and Tumor necrosis factor alpha (TNF-alpha), and modulation of macrophage polarization by promoting cholesterol efflux. Research is primarily conducted by academic institutions like Zhejiang Chinese Medical University.

Other names: Qinghao-Biejia herb pairArtemisia annua + Carapax Trionycis

Targets

HMGB1 (High mobility group protein B1)MYD88 (Myeloid differentiation primary response protein MyD88)TLR4 (Toll-like receptor 4)IL-6 (Interleukin 6)

Beyond the preview

Go deeper on qinghao + biejia.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on qinghao + biejia.

Explore the full profile