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Qingre Lishi Huoxue Prescription
- Development stage
- Preclinical
- Lead developer
- Hunan University of Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Qingre Lishi Huoxue Prescription (QRLSHXP) is a Traditional Chinese Medicine (TCM) herbal formulation composed of four specific herbs: Sanye Danshen, Jiuguanxue, Shanchagen, and Huaxuedan. Developed by researchers at the Hunan University of Chinese Medicine and Peking University Third Hospital, it is being investigated for its anti-tumor efficacy in esophageal carcinoma. The prescription inhibits cancer cell proliferation and induces pyroptosis, a form of programmed cell death, through the activation of the Caspase-3/GSDME signaling pathway. This process results in increased DNA damage, compromised membrane integrity, and the secretion of inflammatory cytokines such as IL-1β and IL-18.
- Other names
- Qingre Lishi Huoxue Prescription
02
Targets
GSDME (Gasdermin E)CASP3 (Caspase-3)
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