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QingRe-Lishi Recipe is a Traditional Chinese Medicine (TCM) herbal formula developed by Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, affiliated with the Shanghai University of Traditional Chinese Medicine. It is primarily indicated for the treatment of anal fistula, specifically to promote wound healing and reduce inflammatory complications following surgical interventions such as fistulotomy. The formula is designed based on the TCM principle of clearing heat and draining dampness (Qingre Lishi), which translates to anti-inflammatory and anti-edema activities in a clinical setting. Pharmacological studies indicate that the recipe exerts its therapeutic effects by modulating the local inflammatory microenvironment, specifically by inhibiting pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), while potentially upregulating growth factors like vascular endothelial growth factor (VEGF) to facilitate angiogenesis and tissue repair.
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