Drug intelligence / Profile preview

Qingre Zaoshi Liangxue Fang

Development stage: Unknown
Modality: Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration: Oral

Overview

Qingre Zaoshi Liangxue Fang (QRZSLXF) is a traditional Chinese medicinal herb recipe composed of five quality-assured herbs: Sophora flavescens Aiton., Baphicacanthus cusia (Nees) Bremek., Bletilla striata Rchb.f., Glycyrrhiza uralensis Fisch., and Coptis chinensis Franch. Its main phytochemical ingredients include ammothamnine, sophocarpidine, liquiritin, berberine, and indirubin. QRZSLXF has been clinically used for over two decades in the treatment of ulcerative colitis, with research confirming its therapeutic effects and partially elucidating its mechanism of action, specifically its intervention on the DOR-β-arrestin1-Bcl2 signal transduction pathway.

Targets

ARRB1 (Arrestin beta-1)DOR (Opioid Receptor Delta 1)

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