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qingxie fuzheng
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Qingxie Fuzheng (QFG) is a traditional Chinese medicine (TCM) formulation investigated for its therapeutic potential in cancer and cancer-associated cachexia. In preclinical models of colon adenocarcinoma-induced cachexia, QFG has been shown to ameliorate muscle wasting and systemic inflammation by modulating the gut microbiota, restoring intestinal barrier integrity, and suppressing the IL-6/NF-κB signaling pathway. Additionally, in hepatocellular carcinoma (HCC) models, QFG exhibits anti-tumor activity by inducing apoptosis through both the death receptor (Fas/FasL) and mitochondrion-dependent (Bax/Bcl-2) pathways, leading to the activation of the caspase cascade (caspase-3, -8, and -9).
- Other names
- Qingxie Fuzheng GranulesQingjie Fuzheng granules
02
Targets
VEGFR4 (Vascular endothelial growth factor Receptor-3)NOD2 (Nucleotide-binding oligomerization domain-containing protein 2)
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