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Qingyi Huaji
- Development stage
- Phase 3
- Lead developer
- Fudan University Shanghai Cancer Center
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Qingyi Huaji is a traditional Chinese herbal medicine formula developed for the treatment of advanced pancreatic cancer. It has demonstrated efficacy in improving cancer-related symptoms, prolonging survival, and inhibiting tumor growth in preclinical and clinical studies. Its therapeutic effects are mediated through multiple mechanisms, including the down-regulation of Ski expression, modulation of the Notch signaling pathway by decreasing Hes-1 and Hey-1, inhibition of MAPK/ERK and PI3K/Akt/mTOR signaling pathways, reduction of inflammatory cytokines such as IL-6, IL-8, and TNF-alpha, and reprogramming of metabolism via the LINC00346-OMA1-ATF4 signaling pathway.
- Other names
- 清胰化积颗粒剂Qingyi Huaji FormulaQingyi Huaji decoctionQingyihuaji FormulaQingyiHuaji optimized formulaQingyi Huayi formulaQiyi Huaji
02
Targets
HES1 (Hairy and Enhancer of Split 1 Protein)HEY1 (Hairy/enhancer-of-split related with YRPW motif protein 1)IL-6 (Interleukin 6)NANOG (Nanog Homeobox)OMA1-ATF4 (Mitochondrial metallopeptidase OMA1 - Activating transcription factor 4 signaling axis)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)SKI (SKI proto-oncogene)ATF4 (Activating transcription factor 4)OMA1 (Mitochondrial protease OMA1)
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