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Qishen granule optimized prescription
- Development stage
- Preclinical
- Lead developer
- First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Administration
- Oral
01
Overview
Qishen granule optimized prescription is a Traditional Chinese Medicine (TCM) formulation being evaluated for the treatment of chronic heart failure (CHF) and dilated cardiomyopathy (DCM). It is a refined version of the original Qishen granule (QSG), a multi-herb decoction traditionally used in China to improve cardiac function and alleviate symptoms of heart failure. The optimization typically involves adjusting the ratios or specific herbal components to enhance therapeutic efficacy, particularly in modulating myocardial remodeling, improving hemodynamics, and reducing inflammatory markers. In clinical trials, it is often administered as an add-on to standardized Western medical therapy to evaluate its potential in improving clinical outcomes and quality of life for patients with heart failure.
- Other names
- Qishen granule optimized prescriptionQishen granule optimizationOptimized Qishen granule
02
Targets
TLR4 (Toll-like receptor 4)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)HIF1A (Hypoxia-inducible factor 1-alpha)
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