Drug intelligence / Profile preview

Qixue Bingzhi

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Qixue Bingzhi (also referred to as Qi-Xue-Bing-Zhi) is a multi-component Traditional Chinese Medicine (TCM) herbal formulation investigated for its potential therapeutic effects in cardiovascular diseases. The recipe is primarily studied for its ability to inhibit the proliferation of vascular smooth muscle cells (VSMCs), a critical factor in the pathogenesis of atherosclerosis and vascular restenosis. Research has identified several key active components within its effective fractions, including paeoniflorin, naringin, and neohesperidin. The pharmacological mechanism is thought to involve the downregulation of platelet-derived growth factor (PDGF) and its corresponding receptor (PDGFR) gene expression, thereby modulating cellular signaling pathways associated with vascular remodeling.

Other names
Qi-Xue-Bing-ZhiQixue Bingzhi RecipeQixue Bingzhi Decoction
02

Targets

PDGF (Platelet-derived Growth Factor family)PDGFR (PDGFR family)

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