Drug intelligence / Profile preview

Qizhu Feixian Decoction

Development stage
Unknown
Lead developer
Guang'anmen Hospital
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Qizhu Feixian Decoction (QZFXD) is a Traditional Chinese Medicine (TCM) herbal formula developed by Guang'anmen Hospital, affiliated with the China Academy of Chinese Medical Sciences. It is specifically indicated for the treatment of idiopathic pulmonary fibrosis (IPF). The formula is based on TCM principles of tonifying Qi, strengthening the spleen, and resolving blood stasis and phlegm to treat 'lung atrophy.' Clinical research, including the trial ChiCTR2200058641, evaluates its efficacy in improving lung function (FVC, DLCO), exercise capacity (6MWD), and quality of life in patients with IPF. Pharmacological studies suggest it may inhibit the TGF-beta1/Smad signaling pathway, which is a key driver of pulmonary fibrosis.

Other names
Qizhu Feixian DecoctionQizhu Feixian formulaQZFXD
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)

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