Drug intelligence / Profile preview

QL1207

Development stage
Phase 3
Lead developer
Qilu Pharmaceutical
Modality
Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravitreal
01

Overview

QL1207 is a biosimilar to aflibercept, developed by Qilu Pharmaceutical for the treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). It is administered as an intravitreal injection. QL1207 acts as an inhibitor of vascular endothelial growth factor A (VEGF-A) and placenta growth factor, thereby reducing abnormal blood vessel growth and leakage in the retina. Clinical trials have demonstrated that QL1207 has equivalent efficacy, safety, immunogenicity, and pharmacokinetic profiles compared to reference aflibercept in patients with nAMD. It represents the first approved aflibercept biosimilar in China[1][2][4][5][6][7].

Other names
aflibercept biosimilar
02

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