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QL1706 + nab-paclitaxel + cisplatin
- Development stage
- Unknown
- Lead developer
- Qilu Pharmaceutical
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
QL1706 + nab-paclitaxel + cisplatin is a combination chemo-immunotherapy regimen being evaluated for the first-line treatment of advanced or metastatic esophageal squamous cell carcinoma (ESCC). The regimen consists of QL1706, a novel bifunctional antibody developed by Qilu Pharmaceutical that simultaneously targets the PD-1 and CTLA-4 immune checkpoints, combined with the cytotoxic agents nab-paclitaxel (an albumin-bound microtubule inhibitor) and cisplatin (a platinum-based DNA cross-linking agent). By combining dual checkpoint blockade with standard chemotherapy, the regimen aims to enhance anti-tumor immune responses and improve clinical outcomes. A Phase 2 clinical trial (NCT05614323) sponsored by The First Affiliated Hospital of Henan University of Science and Technology is currently investigating the efficacy and safety of this combination in patients with ESCC.
- Brand names
- AbraxanePlatinol
- Other names
- QL1706 plus nab-paclitaxel and cisplatinQL-1706 plus nab-paclitaxel and cisplatinQL 1706 plus nab-paclitaxel and cisplatinQL1706 + albumin-bound paclitaxel + cisplatin
02
Targets
DNACTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)PDCD1 (Programmed cell death protein 1 receptor)TUBB (Tubulin (alpha and beta subunits))
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