Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
QNZ46
- Development stage
- Preclinical
- Lead developer
- Soochow University
- Modality
- Small Molecules
- Administration
- Oral, Intraperitoneal
01
Overview
QNZ46 is a small molecule negative allosteric modulator (inhibitor) selective for GluN2D-containing N-methyl-D-aspartate (NMDA) receptors. It is primarily utilized as a research tool to investigate the physiological and pathological roles of the GluN2D subunit in the central nervous system. Preclinical studies, including those in 6-OHDA-induced models of Parkinson's disease, suggest that QNZ46 exerts neuroprotective effects by improving mitochondrial function and preventing the degeneration of dopaminergic neurons in the substantia nigra. Its selectivity for GluN2C/D subunits over GluN2A/B makes it a valuable probe for studying subunit-specific NMDA receptor signaling.
- Other names
- QNZ 46QNZ46QNZ-46
02
Targets
GRIN2D (Glutamate receptor ionotropic NMDA subunit 2D)GRIN2A (NMDA receptor subunit 2A)GRIN2B (N-methyl-D-aspartate Receptor Subunit Combination: NR1a/NR2B)GRIN2C (NMDA receptor subunit 2C)
Beyond the preview
Go deeper on QNZ46.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on QNZ46.