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QNZ46
- Development stage
- Preclinical
- Lead developer
- Soochow University
- Modality
- Small Molecules
- Administration
- Oral, Intraperitoneal
01
Overview
QNZ46 is a small molecule negative allosteric modulator (inhibitor) selective for GluN2D-containing N-methyl-D-aspartate (NMDA) receptors. It is primarily utilized as a research tool to investigate the physiological and pathological roles of the GluN2D subunit in the central nervous system. Preclinical studies, including those in 6-OHDA-induced models of Parkinson's disease, suggest that QNZ46 exerts neuroprotective effects by improving mitochondrial function and preventing the degeneration of dopaminergic neurons in the substantia nigra. Its selectivity for GluN2C/D subunits over GluN2A/B makes it a valuable probe for studying subunit-specific NMDA receptor signaling.
- Other names
- QNZ 46QNZ46QNZ-46
02
Targets
GRIN2A (NMDA receptor subunit 2A)GRIN2B (N-methyl-D-aspartate Receptor Subunit Combination: NR1a/NR2B)GRIN2C (NMDA receptor subunit 2C)GRIN2D (Glutamate receptor ionotropic NMDA subunit 2D)
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