Drug intelligence / Profile preview

QQ21

Development stage
Preclinical
Lead developer
Henan Normal University
01

Overview

QQ21: sourced facts only. name: "Structure activity relationship investigation demonstrated that compound QQ21 showed significant improved STING inhibition activity in mouse RAW-Lucia™ ISG cells with an IC50 value of 86 nM, which is 8-fold of the efficacy of H151." [PMID:41534479]; target: "Structure activity relationship investigation demonstrated that compound QQ21 showed significant improved STING inhibition activity in mouse RAW-Lucia™ ISG cells with an IC50 value of 86 nM, which is 8-fold of the efficacy of H151." [PMID:41534479]; developer: "Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, PR China." [PMID:41534479]; stage: "In cisplatin-induced acute kidney injury (AKI) mouse model, QQ21 significantly prevented kidney function damage and inflammation." [PMID:41534479]

02

Targets

STING (Stimulator of interferon genes protein)

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