Drug intelligence / Profile preview

QRH-882260

Development stage: Phase 1
Lead developer: University of Michigan
Modality: Small Molecules, Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Recombinant Proteins and Enzymes
Administration: Oral, Topical, Intraductal

Overview

QRH-882260 is an orally bioavailable, fluorescent-labeled heptapeptide imaging agent. It consists of a seven-amino acid peptide conjugated to the near-infrared fluorophore cyanine 5 (Cy5). The peptide specifically binds to the tumor-associated antigen epidermal growth factor receptor (EGFR), which is overexpressed in various neoplasms. By targeting EGFR, QRH-882260 enables real-time fluorescence imaging of neoplastic tissues during endoscopic procedures, such as colonoscopy and ERCP for biliary disorders. Its primary use has been as a diagnostic dye for detecting and delineating cancerous or dysplastic lesions in the digestive tract[1][2][4][7].

Other names: imaging agent QRH-882260 heptapeptide

Targets

EGFR (Epidermal growth factor receptor)

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