QS11

QS11 is a cell-permeable, small-molecule purine derivative that acts as a synergistic agonist of the Wnt/β-catenin signaling pathway. It achieves this effect by binding to and inhibiting ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1). This inhibition prevents the inactivation of ADP-ribosylation factors (ARFs) such as ARF1 and ARF6, thereby modulating protein trafficking and promoting β-catenin nuclear translocation. QS11 has been shown to inhibit the migration of ARFGAP1-overexpressing metastatic breast cancer cells and to promote adrenergic and non-adrenergic prostate smooth muscle contraction. It is primarily utilized as a research tool to study Wnt signaling, protein trafficking, and smooth muscle physiology.

Other names

(2S)-2-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-(2,3-dihydro-1H-inden-5-yloxy)-9H-purin-6-yl]amino]-3-phenyl-1-propanol(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-olQS 11QS11QS-11