Drug intelligence / Profile preview

Quadracel

Development stage
Approved
Lead developer
Sanofi Pasteur
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Quadracel is a combination vaccine developed by Sanofi Pasteur for active immunization against diphtheria, tetanus, pertussis, and poliomyelitis. It is specifically indicated for use as a fifth dose in the DTaP series and a fourth or fifth dose in the IPV series for children aged 4 through 6 years whose previous doses were with specific DTaP-containing vaccines (such as Pentacel, Daptacel, or Vaxelis). The vaccine is a sterile suspension containing diphtheria and tetanus toxoids, acellular pertussis antigens (pertussis toxoid, filamentous haemagglutinin, pertactin, and fimbriae types 2 and 3), and inactivated poliovirus types 1, 2, and 3, all adsorbed onto an aluminum phosphate adjuvant. Quadracel is designed to simplify the vaccination schedule by reducing the number of injections required during the preschool booster visit.

Brand names
QuadracelTetraximTetravac
Other names
DTaP-IPVDTacP-IPVdiphtheria, tetanus, pertussis (acellular) and poliomyelitis (inactivated) vaccine (adsorbed)
02

Targets

FHA (Filamentous hemagglutinin)PRN (Pertactin)FIM2/FIM3 (Fimbriae types 2 and 3)WPV3 (Poliovirus type 3 capsid protein)Poliovirus type 1 capsid proteinDiphtheria toxin

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