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Quadrivalent influenza mRNA vaccine MRT5410 is an investigational messenger RNA (mRNA) vaccine designed to protect against four strains of the influenza virus. The vaccine uses mRNA technology to encode antigens from these strains, prompting the body’s cells to produce viral proteins that stimulate an immune response. This approach aims to induce both humoral and robust T-cell immunity against seasonal flu viruses. The formulation typically involves encapsulating the mRNA in lipid nanoparticles for delivery and stability. Developed by Sanofi, this candidate is being evaluated for safety and immunogenicity in adults aged 18 years and older[2][3][5]. As of early 2024, it is undergoing Phase 1/Phase 2 clinical trials.
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