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comparator-Eurocine Vaccines AB-influenza refers to the quadrivalent inactivated influenza vaccine (QIV) used as an active control in clinical trials conducted by Eurocine Vaccines AB, such as the Phase I/II study for the intranasal vaccine candidate Immunose FLU. This comparator is a standard-of-care vaccine administered via intramuscular injection, containing 15 μg of hemagglutinin (HA) per strain for four influenza strains (typically two influenza A subtypes and two influenza B lineages). It serves as the benchmark for evaluating the safety and immunogenicity of experimental influenza vaccines, particularly in measuring serum antibody responses via hemagglutination inhibition (HI) assays. While the specific brand used in the trial (e.g., VaxigripTetra or Fluarix Tetra) is often not disclosed in early-phase summaries, it follows the standard specifications for licensed quadrivalent influenza vaccines.
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