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Quadrivalent recombinant norovirus vaccine (Pichia pastoris) is an investigational, recombinant virus-like-particle vaccine developed by Anhui Zhifeilongkema Biopharmaceutical for prevention of acute gastroenteritis caused by norovirus. The product is produced using a *Pichia pastoris* expression system and is intended to generate protective immune responses against multiple norovirus variants. It has progressed from Phase I/IIa evaluation in people aged 6 weeks and older to a randomized, placebo-controlled Phase III efficacy, immunogenicity, and safety study in children aged 6 weeks to 13 years. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04563533))
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