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The quadrivalent split virion influenza vaccine is an inactivated vaccine designed to provide protection against four different influenza virus strains: two influenza A subtypes (typically H1N1 and H3N2) and two influenza B lineages (Victoria and Yamagata). The 'split virion' technology involves disrupting the virus particles with detergents, which maintains the immunogenicity of the hemagglutinin and neuraminidase proteins while reducing the risk of reactogenicity compared to whole-virus vaccines. This vaccine type is a standard for seasonal influenza prevention and is developed by various manufacturers, including the Changchun Institute of Biological Products and Jiangsu Jindike Biotechnology. It is typically administered as a single intramuscular dose to adults and children to stimulate the production of neutralizing antibodies against the hemagglutinin protein of the included strains.
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