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Qubi Yangge Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by Longhua Hospital, affiliated with the Shanghai University of Traditional Chinese Medicine. It is primarily indicated for the treatment of early to mid-stage knee osteoarthritis (KOA). The decoction is typically administered orally and is often evaluated as part of a comprehensive TCM intervention strategy that includes the "whole-knee three-steps-nine-methods" manual therapy and specific leg exercises. In clinical trials, it has been studied for its ability to reduce joint pain and swelling, improve physical function, and enhance the quality of life in patients with KOA, often compared against standard pharmacological treatments like celecoxib and glucosamine. As a complex herbal mixture, its mechanism involves multi-target anti-inflammatory and chondroprotective actions characteristic of TCM treatments for "Bi-syndrome" (painful obstruction syndrome).
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