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Drug intelligence / Profile preview
quercetagetin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Quercetagetin is a naturally occurring flavonoid, specifically a hexahydroxyflavone, derived from plants such as *Flos eriocauli* (the flower of *Eriocaulon buergerianum*). It is traditionally used in Chinese medicine for its anti-inflammatory and analgesic properties. Research indicates it has potential therapeutic applications in rheumatoid arthritis by alleviating inflammatory osteoclastogenesis. Its mechanism involves the activation of the Nrf2 signaling pathway and the modulation of the Pten/AKT/Nfatc1 axis. Additionally, quercetagetin is recognized as a potent, ATP-competitive inhibitor of PIM1 kinase, suggesting potential utility in oncology and other inflammatory conditions.
- Other names
- 3,3',4',5,6,7-hexahydroxyflavone6-hydroxyquercetin
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)KEAP1 (Kelch-like ECH-associated protein 1)NFKB1 (NF-κB1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NFATC1PIM1 (Proviral integration site for moloney murine leukemia virus kinase 1)
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