quercetin-3-docosahexaenoic acid-7-isopropyl

Quercetin-3-docosahexaenoic acid-7-isopropyl is a synthetic polyunsaturated alkylated lipophenol designed as a hybrid molecule for the treatment of neurodegenerative diseases, specifically Alzheimer's disease. It is a single pharmacological entity that covalently combines the antioxidant and anti-carbonyl stress properties of the flavonoid quercetin with the anti-inflammatory benefits of the omega-3 fatty acid docosahexaenoic acid (DHA), further modified with an isopropyl group at the 7-position to enhance lipophilicity or stability. The molecule acts by scavenging toxic small aldehydes like acrolein and reducing oxidative stress, thereby protecting neuronal cells from carbonyl stress-induced apoptosis. Research indicates that this hybrid structure may offer superior neuroprotective effects compared to its individual components by addressing multiple detrimental mechanisms involved in neuronal cell loss.

Other names

quercetin-3-docosahexaenoic acid-7-isopropyl lipophenolquercetin3-docosahexaenoic acid-7-isopropyl lipophenolquercetin 3-docosahexaenoic acid-7-isopropyl lipophenolalkyl quercetin lipophenol