quercetin-7-isopropyl

quercetin-7-isopropyl (7-O-isopropylquercetin) is a semi-synthetic alkylated derivative of the natural flavonoid quercetin. By substituting the hydroxyl group at the C-7 position with an isopropyl ether group, the molecule exhibits enhanced lipophilicity and potentially improved metabolic stability compared to parent quercetin. It is primarily recognized for its anti-carbonyl and oxidative stress (anti-COS) properties, specifically its ability to protect neuronal cells from carbonyl stress induced by toxic aldehydes such as acrolein. This compound is also a critical structural component and synthetic intermediate for polyunsaturated lipophenols, such as quercetin-3-docosahexaenoic acid-7-isopropyl, which are being developed as multifunctional agents for neurodegenerative disorders like Alzheimer's disease. Research conducted by the CNRS and the University of Montpellier has highlighted its potential in alleviating harmful mechanisms associated with neuronal cell loss.

Other names

7-O-isopropylquercetin7-isopropylquercetin7-iPr-quercetin7-isopropyl quercetin