Drug intelligence / Profile preview

quercetin dihydrate

Development stage
Preclinical
Lead developer
Sichuan Lele Pharmaceutical Technology Development
Modality
Small Molecules
Administration
Oral
01

Overview

Quercetin dihydrate is a flavonoid small molecule and a specific hydrate form of quercetin, a naturally occurring polyphenolic compound found in various fruits, vegetables, and grains. It is developed and manufactured by Sichuan Lele Pharmaceutical Technology Development (also known as Sichuan Xieli Pharmaceutical) as part of their portfolio of rutin derivatives. Quercetin is widely recognized for its potent antioxidant, anti-inflammatory, and potential senolytic properties. Its mechanism of action involves scavenging reactive oxygen species (ROS) and inhibiting several key enzymes involved in inflammatory pathways, such as cyclooxygenase (COX) and lipoxygenase (LOX). Additionally, it has been shown to inhibit phosphoinositide 3-kinase (PI3K) and other signaling kinases, which may contribute to its anti-proliferative and cardiovascular protective effects. It is commonly used as a dietary supplement and is under investigation for various therapeutic applications, including cardiovascular health, metabolic disorders, and viral infections.

Other names
quercetin dihydratequercetin3,3',4',5,7-pentahydroxyflavone dihydratesophoretin
02

Targets

ALOX12 (Arachidonate 12-lipoxygenase, 12S type)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ALOX5 (Arachidonate 5-lipoxygenase)PIK3CA (Phosphoinositide 3-kinase alpha)

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