Drug intelligence / Profile preview

quercetin phytosome

Development stage
Preclinical
Lead developer
Indena
Modality
Small Molecules, Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Oral
01

Overview

Quercetin phytosome is a highly bioavailable formulation of **quercetin**, a naturally occurring flavonoid, combined with a phospholipid (typically sunflower lecithin) via Phytosome® technology[1][2][4]. This optimized delivery system overcomes quercetin’s poor oral bioavailability and limited absorption, enhancing its therapeutic efficacy[1][4]. **Mechanism of action:** - Inhibits **xanthine oxidase**, thus reducing uric acid production and exerting a hypouricemic effect for hyperuricemia management[1]. - Displays antioxidant, antiviral, immunomodulatory, and anti-inflammatory properties[1][2][4]. - Demonstrates senolytic activity, potentially targeting and eliminating senescent cells—this is relevant for COVID-19 and related inflammatory states[4]. Clinical evidence supports its use as an adjunct therapy for hyperuricemia and triglyceride lowering[1], and as a complementary agent for early-stage COVID-19, with demonstrated benefits in viral clearance, symptom improvement, and inflammatory marker reduction[2][4]. Quercetin phytosome’s source compound is typically extracted from Sophora japonica L.[4]. Developed specifically for improved drug delivery by enhancing stability, absorption, and pharmacological activity via the phytosome system[3][4].

Brand names
Quercetin PhytosomeQuevir
Other names
QPQuercetin Phytosome™Quercetin Phytosome®QNPQuercetin-loaded nanophytosome
02

Targets

PI3K (Phosphoinositide-3-kinase regulatory subunit 6)TtgR (TtgABC operon repressor)XO (Xanthine Oxidoreductase)LOX (Arachidonate 12-lipoxygenase, 12R-type)FabZ (3-hydroxyacyl-ACP dehydratase FabZ)

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