Drug intelligence / Profile preview

quercus salicina extract

Development stage
Phase 3
Lead developer
Nippon Shinyaku
Modality
Small Molecules
Administration
Oral
01

Overview

Quercus salicina extract, often referred to by the brand names **Ucalon** or **Urocalun**, is a botanical pharmaceutical preparation developed by Japan New Drug Co., Ltd. (Nippon Shinyaku). Derived from the leaves of the *Quercus salicina* (Urajirogashi) tree, it is specifically indicated for the promotion of the discharge of kidney and ureteral stones (urolithiasis). The extract is believed to exert its therapeutic effects through a multifaceted mechanism that includes inhibiting the formation, growth, and aggregation of calcium oxalate crystals, which are the primary components of most urinary calculi. Additionally, it possesses anti-inflammatory and spasmolytic properties that help reduce edema in the urinary tract and relax the smooth muscles of the ureter, thereby facilitating the spontaneous passage of stones. It is widely utilized in East Asian markets, particularly Japan and China, as a conservative management option for patients with small urinary stones.

Brand names
UcalonUrocalunYoukelong
Other names
Urajirogashi extractQuercus salicina Blume extract

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