quinaverine

Quinaverine is a small molecule antispasmodic agent that functions as a selective inhibitor of phosphodiesterase 4 (PDE4). By inhibiting PDE4, it increases intracellular levels of cyclic adenosine monophosphate (cAMP), which leads to the relaxation of smooth muscles in the gastrointestinal, biliary, and urinary tracts. It is chemically related to papaverine but exhibits higher potency and fewer side effects. Quinaverine is primarily developed for the treatment of conditions involving smooth muscle spasms, such as irritable bowel syndrome (IBS), biliary colic, renal colic, and dysmenorrhea. In China, Jiangxi Yiyou Pharmaceutical is conducting bioequivalence studies comparing quinaverine hydrochloride tablets to the reference drug NO-SPA (drotaverine), indicating its development as a generic alternative to drotaverine.

Other names

quinaverine hydrochloride盐酸喹那维林