Drug intelligence / Profile preview

Qutan Huoxue Formula

Development stage
Preclinical
Lead developer
Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University
Administration
Oral
01

Overview

Qutan Huoxue Formula (also known as Qutan Huoxue decoction or QTHX) is an empirically developed traditional Chinese medicine (TCM) formula used for the treatment of metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH). The formula is composed of multiple herbal ingredients, including Pinellia ternata, Citrus sinensis, Salvia miltiorrhiza, Coix lacryma-jobi, Bupleurum scorzonerifolium, Alisma plantago-aquatica, Cassia tora, Poria cocos, and Scutellaria baicalensis. It has been shown to reduce hepatic lipid deposition, attenuate hepatic oxidative stress, and inhibit MASH progression. Mechanistically, Qutan Huoxue Formula acts by regulating CYP1B1-mediated arachidonic acid metabolism, upregulating SOCS1, and inhibiting the TLR4/NF-κB inflammatory signaling pathway.

Other names
Qutan Huoxue decoctionQutan Huoxue granule祛痰活血方祛痰活血颗粒
02

Targets

CYP1B1 (Cytochrome P450 1B1)

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