Drug intelligence / Profile preview

quyushengxin

Development stage
Preclinical
Lead developer
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of T.C.M
Administration
Oral, Rectal
01

Overview

Quyushengxin (QYSX) is a traditional Chinese medicine (TCM) formula being investigated for the treatment of mild-to-moderate ulcerative colitis (UC). [1, 2] The formula is primarily composed of four herbs: Panax ginseng, Astragalus membranaceus, Pulsatilla chinensis, and Coptis chinensis. [2] Clinical studies have shown that Quyushengxin, both alone and in combination with mesalazine, can relieve clinical symptoms, suppress inflammation, and improve the quality of life for UC patients. [1] Its mechanism of action is believed to be multifactorial, involving the regulation of the gut microbiome and bacteriophages, restoring the balance of gut flora. [3] Research also suggests it works by modulating bile acid metabolism and promoting the polarization of macrophages from a pro-inflammatory M1 state to an anti-inflammatory M2 state, which helps reduce inflammation and promote tissue repair. [10]

Brand names
kuijie formula
Other names
Quyushengxin formulaquyushengxin recipestasis removing and renewal therapy祛瘀生新方
02

Targets

RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)RELA (Nuclear Factor Kappa B Subunit p65)TNFA (Tumor necrosis factor alpha (soluble))RIPK3IL-6R (Interleukin-6 receptor subunit alpha)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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