r-phenylephrine

r-phenylephrine is the dextrorotatory enantiomer of phenylephrine, a **small-molecule sympathomimetic alpha-1 adrenergic receptor agonist** used clinically as a vasoconstrictor and decongestant. The provided sources specifically discuss r-phenylephrine as the desired chiral product of biocatalytic synthesis from 1-(3-hydroxyphenyl)-2-(methylamino) ethanone using engineered or recombinant *Serratia marcescens* short-chain dehydrogenase/reductase systems, rather than as a novel proprietary development program. Pharmacologically, the active therapeutic effect is mediated primarily through stimulation of alpha-1 adrenergic receptors on vascular smooth muscle, producing vasoconstriction; this underlies uses such as nasal decongestion and hemodynamic support depending on formulation and route. The drug is an established pharmaceutical ingredient rather than a combination product, device, supplement, or biologic.

Other names

(R)-phenylephriner-phenylephrine(R)-PE