r-propranolol

r-propranolol is the R(+)-enantiomer of propranolol, a nonselective beta-adrenergic receptor antagonist, isolated from the usual racemic mixture in which the S(–)-enantiomer is primarily responsible for beta-blocking activity. As a single enantiomer, r-propranolol has markedly lower affinity for β1- and β2-adrenergic receptors than s-propranolol and is mainly of interest as a pharmacological tool and research compound to study stereoselective pharmacokinetics and pharmacodynamics of propranolol rather than as a therapeutic agent. It is a small-molecule synthetic beta-blocker derivative and shares the general physicochemical properties and metabolic pathways of propranolol, but with substantially reduced beta-adrenergic antagonism.