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R21 + AS01B
- Development stage
- Preclinical
- Lead developer
- University of Oxford
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
R21 + AS01B is a malaria vaccine formulation combining the R21 antigen with the AS01B adjuvant. R21 is a malaria vaccine candidate that targets the circumsporozoite protein (CSP) of the Plasmodium parasite, which blocks the parasite from entering the liver. The R21 component consists of virus-like particles built from scaffolding derived from the hepatitis B virus, with a high proportion of malaria protein antigen (CSP) on its surface. While R21 is more commonly paired with Matrix-M adjuvant in clinical trials, this specific formulation uses AS01B, which is a liposomal adjuvant containing the immunostimulants MPL and QS-21.
- Other names
- R21 + ASO1B-University of Oxford-malariaR21/AS01BR21 with AS01BR-21 with AS01BR 21 with AS01B
02
Targets
CSP (Circumsporozoite protein)
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