Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
R44AI165008
- Development stage
- Unknown
- Lead developer
- Prokaryotics
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
R44AI165008 is a first-in-class parenteral small molecule antibiotic developed by Prokaryotics. It functions as an inhibitor of Penicillin-binding protein (PBP) transglycosylase, an essential enzyme involved in the synthesis of the bacterial peptidoglycan cell wall. Unlike traditional beta-lactam antibiotics that target the transpeptidase activity of PBPs, R44AI165008 targets the transglycosylase domain, providing a novel mechanism of action against multidrug-resistant (MDR) Gram-negative pathogens. The drug is specifically being developed for the treatment of infections caused by multidrug-resistant *Acinetobacter baumannii* and is intended for use in combination with polymyxin antibiotics to enhance bactericidal activity. The program has been supported by the National Institute of Allergy and Infectious Diseases (NIAID) and reached Phase 1 clinical development.
- Other names
- PBP-Transglycosylase inhibitor
02
Targets
PBP (Penicillin-binding protein family)
Beyond the preview
Go deeper on R44AI165008.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on R44AI165008.