R9-SOCS3-KIR

R9-SOCS3-KIR is a cell-penetrating peptide designed to mimic the kinase inhibitory region (KIR) of the Suppressor of Cytokine Signaling 3 (SOCS3) protein. It consists of residues 20–35 of the human SOCS3 KIR sequence linked to a nona-arginine (R9) sequence at the N-terminus to facilitate penetration across biological membranes. The peptide acts as an intracellular checkpoint inhibitor by mimicking the endogenous SOCS3 protein, which regulates the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and toll-like receptor (TLR) signaling pathways. Specifically, it inhibits the activation and nuclear translocation of STAT3, NF-κB p65, and p38 MAPK. Developed by researchers at the University of Florida, R9-SOCS3-KIR is being investigated for its potential to treat ocular diseases driven by inflammation and oxidative stress, such as age-related macular degeneration (AMD) and retinal injury, through topical ophthalmic administration.

Other names

SOCS3-KIR peptideSOCS-3-KIR peptideSOCS 3-KIR peptidecell-penetrating SOCS3-KIR peptide