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rAAV-sh-NeuroD1
- Development stage
- Unknown
- Lead developer
- The Pennsylvania State University
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies
- Administration
- Intrathecal, Intralesional
01
Overview
rAAV-sh-NeuroD1 is a recombinant adeno-associated virus (rAAV) vector designed to deliver a short hairpin RNA (shRNA) targeting the Neurogenic differentiation 1 (NeuroD1) gene. It is primarily utilized as a research tool in neuroscience to investigate the functional role of NeuroD1 in processes such as adult neurogenesis, neuronal differentiation, and survival. By leveraging the RNA interference (RNAi) pathway, the vector mediates the knockdown of NeuroD1 expression in specific brain regions, such as the dentate gyrus of the hippocampus. While NeuroD1 overexpression is being explored therapeutically for in vivo cell reprogramming (e.g., converting astrocytes into neurons), the shRNA-mediated knockdown version is typically employed in loss-of-function studies to elucidate the transcription factor's necessity in neural development and maintenance.
- Other names
- rAAV-shRNA-NeuroD1rAAV-shRNA-NeuroD-1rAAV-shRNA-NeuroD 1AAV-shRNA-NeuroD1AAV-shRNA-NeuroD-1AAV-shRNA-NeuroD 1
02
Targets
ADRB2 (β2)
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