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rAAV1-HGF
- Development stage
- Unknown
- Lead developer
- AnGes
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies
- Administration
- Intramuscular
01
Overview
rAAV1-HGF is a gene therapy product consisting of a recombinant adeno-associated virus serotype 1 (rAAV1) vector engineered to deliver the human hepatocyte growth factor (HGF) gene. The therapy is designed to induce expression of HGF in target tissues, leveraging HGF's known roles in promoting angiogenesis, tissue regeneration, and anti-fibrotic effects. rAAV vectors are non-pathogenic and have been widely used for in vivo gene delivery due to their safety profile and ability to mediate long-term transgene expression. The primary indications under investigation for rAAV1-HGF include peripheral artery disease (PAD), critical limb ischemia (CLI), and other conditions where enhanced vascularization or tissue repair is beneficial.
- Other names
- recombinant adeno-associated virus serotype 1 encoding hepatocyte growth factorAAV1-HGFAAV-1-HGFAAV 1-HGF
02
Targets
MET (Mesenchymal-epithelial transition factor receptor)
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